12 papers
This study reveals that multisystem inflammatory syndrome in children (MIS-C) is driven by a mechanism of cooperative molecular mimicry, where SARS-CoV-2-specific T cells cross-react with self-antigens involved in prostaglandin biology and insulin metabolism, leading to persistent subclinical autoinflammation even after clinical recovery.
This multi-cohort transcriptomic analysis of 150 Systemic Lupus Erythematosus patients demonstrates that the strength of the Type I interferon signature significantly correlates with alloimmunization-associated gene expression programs, suggesting IFN-I activity as a potential biomarker for transfusion-related alloimmunization susceptibility in SLE.
LM-QASAS is a reference-free computational framework that leverages antibody language models and repertoire dynamics to accurately identify antigen-specific B-cell receptor sequences in emerging pathogens without relying on prior antibody databases.
This multicentre observational study in Singapore demonstrates that 3D facial analysis powered by AI can identify distinct digital biomarkers, such as periorbital swelling, to monitor flare-ups in Hereditary Angioedema, offering a promising non-invasive tool for disease management in rare conditions.
This study quantifies the systemic persistence and transcript integrity of three mRNA-LNP vaccine platforms in humans, revealing that mRNA-1273 exhibits the fastest decay of both intact mRNA and ionizable lipids compared to BNT162b2 and an investigational RBD vaccine, while demonstrating platform-specific coupling between lipid and mRNA kinetics.
This study identifies a novel homozygous gain-of-function UNC93B1 variant (R95L) that drives early-onset lupus and immune dysregulation by enhancing antigen presentation and T cell activation in dendritic cells, expanding the known pathogenic mechanisms of UNC93B1 beyond its established role in TLR trafficking.
This study identifies a novel dominant-negative RIG-I variant (G731R) in a severe COVID-19 patient that locks the receptor in a signaling-inactive state by disrupting ATPase activity and preventing signaling domain exposure, thereby causing critical antiviral deficiency.
This study demonstrates that adenoviral vector vaccines overcome immunosuppression in kidney transplant recipients by sustaining antigen expression and reprogramming lipid metabolism to activate immune cells, thereby eliciting superior antibody and T-cell responses compared to traditional protein vaccines.
This study systematically maps the landscape of known HPV T-cell epitopes to reveal a heavy bias toward E6/E7 proteins and high-risk types while identifying critical gaps in conserved regions like L2, thereby providing essential data to guide the development of next-generation pan-HPV vaccines and immune-monitoring strategies.
By integrating diverse data from the CHILD Cohort Study into the CHILDdb platform, researchers conducted Exposome-Wide Association Studies and machine learning analyses to identify specific early-life exposures, such as antibiotic use and prenatal cleaning product contact, that drive heterogeneous asthma endotypes through epigenetic and microbiome mechanisms, thereby highlighting potential targets for early intervention.
This study utilizes high-dimensional CyTOF profiling to reveal that gestational diabetes mellitus induces distinct, transiently activated immune phenotypes in maternal T cells and innate lymphoid cells before delivery, as well as a more activated, effector-skewed immune landscape in fetal T and B cells at birth.
This study demonstrates that in healthy humans, colonic pH and microbial metabolism jointly shape the peripheral immune landscape, with lower pH associated with cytokine-producing CD8+ T cells and higher pH linked to pre-exhausted CD8+ T cells and elevated neutrophils.